Epub 2013 Jun 29. the CHOP regimen consisting of three chemotherapy drugs (cyclophosphamide, hydroxydoxorubicin, and oncovin) plus a glucocorticoid, either prednisone or prednisolone)[15] achieve complete response rates of 48% to 85%, 3-year overall survival rates of 50% to 64%, and 5 year overall survival rates of 46% to 58%. Using data from the National Cancer Data Base, 2010-2015, we examined characteristics and outcomes of T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL, N = 622) relative to unspecified diffuse large B-cell lymphoma (DLBCL-NOS, N = 91,588) and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL, N = 2240). Computed tomography (CT) scan showed a diffuse and massive thyroid tumor narrowing the tracheal lumen (Figure 1a). To view unlimited content, log in or register for free. These patients must be referred for transplant which can be allogeneic or autologous depending on the primary disease. Many studies have found that THRLBCL can overlap with the variant form of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL).

Ki 67 staining was approximately 30% with preferential staining of the larger cells [Figure 1]. He responded well and subsequently the dose of intravenous steroids was reduced and he was switched to oral Prednisone. [4], T-cell/histiocyte-rich large B-cell lymphoma most commonly afflicts middle-aged (i.e. Google Scholar, Bouadallar R, Mounier N, Guettier C, Molina T, Ribrag V, Thieblemont C, et al. The patient remains in remission after six months of completion of therapy. Five-year overall survival with R-CHOP is reported at 46% [1, 2]. To our knowledge, this is the first case report of THRLBCL exclusively arising in the thyroid.

SI, First Author and Corresponding Author, was in charge of the patient’s treatment, collected the patient information, reviewed the literature, and drafted the manuscript, and revised the final manuscript.

Epub 2015 Feb 2. THRLBCL is considered an aggressive lymphoma, although a considerable amount of clinical variability is described. AHSCT: autologous hematopoietic stem cell transplant; BM: bone marrow; DA-R-EPOCH: dose adjusted Rituximab, Etoposide, Prednisone, Vincristine (Oncovin), Cyclophosphamide, and Doxorubicin; DOE: dyspnea on exertion; DOD: died of disease; IT-MTX: intrathecal methotrexate; LN: lymph node; M: months; MOPP-ABV: mechlorethamine, vincristine, procarbazine, prednisone/doxorubicin bleomycin, and vincristine; MP: methylprednisolone; ND: not described; R-CHOP: Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone. These large-scale epidemiologic data support the relationship between THRLBCL and NLPHL, and suggest improved prognosis with modern rituximab-based immunochemotherapy. YW and KS assisted in treating the patient and collecting the relevant clinical data. (1a) Computed tomography of the thyroid tumor.
Before making a diagnosis of THRLBCL in a pediatric population, congenital and acquired immunodeficiency diseases, which can cause aberrant immune responses with a histology similar to THRLBCL, must be ruled-out. 2011;15(4):358-359. There were no B symptoms. De Wolf-Peeters C, Delabie J, Campo E, Jaffe ES, Delsol G. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, ed. Complete response was confirmed after the completion of six courses of R-CHOP regimen. She was successfully treated by standard rituximab-containing chemotherapy.

A >80% overall response rate was obtained by chemoimmunotherapy, with a 5-year overall survival of approximately 50% (El Weshi et al., 2007). She was successfully treated by chemotherapy consisting of rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and PSL (R-CHOP) without any major issues including tracheal problems. Franke S, Wlodarska I, Maes B, Vandenberghe P, Achten R, Hagemeijer A, De Wolf-Peeters C. La Starza R, Aventin A, Falzetti D, Stul M, Martelli MF, Falini B, Mecucci C. Poppe B, De Paepe P, Michaux L, Dastugue N, Bastard C, Herens C, Moreau E, Cavazzini F, Yigit N, Van Limbergen H, De Paepe A, Praet M, De Wolf-Peeters C, Wlodarska I, Speleman F. Genes Chromosomes Cancer. popcorn and Reed-Sternberg cells. Following the diagnosis of THRLBCL, the patient was treated with R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) given the lack of data to support use of a more aggressive regimen such as DA-R-EPOCH (dose-adjusted Rituximab, Etoposide, Prednisone, Vincristine (Oncovin), Cyclophosphamide, and Doxorubicin).

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