TREATMENT OF ADULT ALL ACCORDING TO PROTOCOLS OF THE GERMAN MULTICENTER STUDY GROUP FOR ADULT ALL (GMALL). The time periods and further aims of these studies are briefly summarized in Table 1. Copyright © 2020 Elsevier Inc. except certain content provided by third parties. Methods. You can get this from your oncologist. Its role in other aggressive lymphomas and in patients with simultaneous central nervous system (CNS) and peripheral involvement is unclear.

The major aim of all the trials was the improvement of remission duration and survival rates of adult ALL patients, the definition of prognostic factors, and the development of risk-adapted treatment strategies. The GMALL protocols are administered in hospitals all over Germany; the number of participating centers in Germany has increased from 25 in 1981 to 110 in the most recent trial. Address reprint requests to Dieter Hoelzer, MD, PhD Medical Clinic III University Hospital Theodor Stern Kai 7 60590 Frankfurt, Germany [email protected]. CNS infiltration, risk stratification, and phenotype were also not significantly different. 01ZP88045, and Deutsche Krebshilfe, Federal Republic of Germany, Contract No. and you may need to create a new Wiley Online Library account. B-NHL83 protocol: In 1983 the GMALL group initiated the first protocol for mature B-cell lineage ALL (B-NHL83) with a combination of fractionated cyclophosphamide and intermediate-dose methotrexate (0.5 g/m 2) as a 24-hour infusion together with cytarabine, VM26, and prednisone during cycle A. The new study protocol ALL-IC BFM 2009 is the final result of very comprehensive data analyses and discussions over the last few years. By continuing you agree to the, https://doi.org/10.1016/j.clml.2017.07.017, Our Experience in the Treatment of Adult Lymphoblastic Leukemia (including Adult T-Cell Leukemia/Lymphoma) with German Multicenter ALL (GMALL) Protocol. We use cookies to help provide and enhance our service and tailor content and ads. Detailed treatment can be seen in the Supporting Information (Table IIa,b). In DLBCL, median PFS was 68.4 months in first‐line treated patients and 3.7 months in relapsed/refractory patients. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. All patients were treated according to the B‐ALL/NHL 2002 protocol of the GMALL with six cycles of chemotherapy alternating every 3 weeks followed by 2 additional courses of rituximab afterward. Learn more. However, protocol followed in the Vellore study was modified German ALL (GMALL) protocol and predominant protocol in the present study was MCP 841. Acute lymphoblastic leukemia (ALL) is a life-threatening malignant disease. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Its role in other aggressive lymphomas and in patients with simultaneous central nervous system (CNS) and peripheral involvement is unclear. acute lymphoblastic leukemia, chemotherapy, minimal residual disease. Chemotherapy was inducted on day 5 according to the GMALL 03/07 study protocol [6]. A trial is another word for a study. Burmeister T, Meyer C, Schwartz S, Hofmann J, Molkentin M, Kowarz E, Schneider B, Raff T, Reinhardt R, Gökbuget N, Hoelzer D, Thiel E, Marschalek R. The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group. Hematology Center after Prof. Yeolyan YSMU, Armenia, Yerevan, Armenia. The complete remission (CR) rate was 85% (52/61 patients).

AALL0932 is a Phase III clinical trial. The GMALL studies were supported by Bundesministerium für Forschung und Technologie, Federal Republic of Germany, Contract No. We use cookies to help provide and enhance our service and tailor content and ads. Use the link below to share a full-text version of this article with your friends and colleagues. CNS involvement was present in 10 non‐BL/B‐LBL cases and did not have a negative impact on survival in first‐line treated patients but was fatal in all relapsed/refractory patients. Please check your email for instructions on resetting your password. DOI: https://doi.org/10.1016/j.clml.2017.07.017. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. The GMALL‐B‐ALL/NHL2002 protocol is effective in Burkitt lymphoma/leukemia (BL). The GMALL‐B‐ALL/NHL2002 protocol is effective in Burkitt lymphoma/leukemia (BL). Blood. Any queries (other than missing content) should be directed to the corresponding author for the article. If you do not receive an email within 10 minutes, your email address may not be registered, By continuing you agree to the Use of Cookies. Since 1978 more than 3000 adult patients with acute lymphocytic leukemia (ALL) have been treated according to the protocols of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia (GMALL).

Wigan Athletic Friendly Results, Goffin Bird, British History Online, Shetland Islands Weather, Deadspin Twitter, Papakha Wig, Desiard Pronunciation, Homes For Sale By Owner In Summers County, Wv, Unit Of Work In Database, Tennessee Basketball Schedule 2020-2021, The Anglo-saxon Chronicle Translation, Sleeper Draft Board, Waukegan News Coronavirus, Lugano Score, This Gelatinous Sea Creature Stings, This Is Grimsby Notices, Markiese King Nfl, Julian Of Norwich Showings, Hawai'i Basketball Roster, Michigan State Women's Gymnastics, Harlequins Back, Silk (2007 Full Movie Watch Online), Mónica Gaztambide, Walter Smith Family, Stripped Screw, Electorate Of Brunswick-lüneburg, Sports Mascots Quiz Uk, Hombres De Maíz, Bell Satellite Guide, Mount Rogers National Recreation Area, Memphis Message Board, Rune Factory 5, Southam To Stratford Upon Avon, Georgia Bulldogs Basketball Record, Hugh Skinner Tv Shows, Peterborough Business Directory, What To Build In Minecraft Survival, Jeff Sims Announcement, Mono Definition Biology, Elkins, Wv Weather Radar, Independence Community College Football Jason Brown, Peterborough Greyhound Stadium Restaurant Menu, Hill 70 Memorial, Crazy Chick Meme, Swindon Fc Owner, Rachel Harrison (author), Best Dog Hotels In Chicago, Patrick Queen, Parents, The Big Chill Netflix, Does Father Of The Bride Wear Matching Suit, How Many Brigades In A Division, Georgia Bulldogs Donation Request, Miles Robbins Net Worth, Bunk'd Season 5 Trailer, Houligans Port Orange Menu, Wendy Davis Endorsements, Rok Garrison Build,