Protocol-driven care bundles improve clinical outcomes, 4, 5 but require early detection of sepsis, which remains elusive even for experienced clinicians. Vasoactive-inotropic score (VIS) is a simpler and more accessible method to describe hemodynamic status. Over the past years, prediction of clinically relevant events through machine learning models has gained particular attention. Introduction. Mortality rates in patients with untreated sepsis can exceed 30%. Troponin can become a prognostic factor in sepsis. 1, 2 As a leading cause of mortality, 3 sepsis represents a significant burden to the patient, clinician, and healthcare system. Providing effective screening tools to nurses is necessary to improve patient outcomes and health care quality. https://onlinelibrary.wiley.com/doi/full/10.1111/acem.12707 However, not all health facilities are equipped to assess troponin levels. Mortality from severe sepsis and sepsis shock improves by 7.6% per hour with early and appropriate administration of antibiotics. Users of the SIRS - Sepsis criteria need to understand that they are overly sensitive to identify potential patients as early as possible, but the criteria lack specificity. The qSOFA (Quick SOFA) Score for Sepsis identifies high-risk patients for in-hospital mortality with suspected infection outside the ICU. This is an unprecedented time. 9 Early identification and treatment of sepsis can also reduce the cost of sepsis-related care. INTRODUCTION. BACKGROUND: Early detection and treatment of sepsis can prevent septic shock and reduce mortality rate. Critical Appraisal of the Literature. The guideline committee identified that the key issues to be included were: recognition and early assessment, diagnostic and prognostic value of blood markers for sepsis, initial treatment, Harnessing and analyzing the vast amounts of physiologic data constantly displayed in ICU patients will lead to improved algorithms for early detection, prognosis, and therapy of critical illnesses. Sepsis is a substantial global health burden and is the leading cause of death among adults in intensive care units (ICUs).1 It affects more than 900,000 people annually in … To evaluate clinically relevant articles regarding the diagnosis and early management of sepsis, severe sepsis, and septic shock, a search of the National Library of Medicine PubMed database was performed using the following search terms: sepsis management, septic shock management, and clinical sepsis treatment guidelines, with a date range of … Sepsis is a major challenge, being present in a large proportion of hospitalizations that culminate in death [1–3].Most sepsis cases seem to arise outside hospital settings [], and these patients present to emergency departments with heterogeneous signs and symptoms, making detection and diagnosis challenging [].New sepsis criteria and early antibiotic treatment has … 10,11 Emergency Department clinicians play a unique role as the first line of care for acutely ill patients. 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