It is soluble in water and slightly soluble in ethanol. If you have any questions, ask your doctor or pharmacist. Patients with asthma should not normally be treated with beta-blockers. Ventolin Solution for Intravenous Infusion should not be administered in the same syringe or infusion as any other medication. Use of VENTOLIN HFA may be associated with the following: The safety data described below reflects exposure to VENTOLIN HFA in 248 patients treated with VENTOLIN HFA in 3 placebo-controlled clinical trials of 2 to 12 weeks’ duration. Consider discontinuation of VENTOLIN HFA if these effects occur. Put the cap back on the mouthpiece. Most of a dose of salbutamol given intravenously, orally or by inhalation is excreted within 72 hours. The counter will stop counting at 000. Adults (including the elderly): For the relief of acute asthma symptoms including bronchospasm, one inhalation (100 micrograms) may be administered as a single minimum starting dose. Adult and Adolescent Patients 12 Years of Age and Older: The efficacy of VENTOLIN HFA was evaluated in two 12-week, randomized, double-blind, placebo controlled trials in patients 12 years of age and older with mild to moderate asthma.

During the double-blind treatment phase, VENTOLIN HFA (91 patients) was compared to CFC 11/12-propelled albuterol (100 patients) and an HFA-134a placebo inhaler (95 patients) in adolescent and adult patients with mild to moderate asthma. The blue actuator supplied with VENTOLIN HFA should not be used with any other product canisters, and actuators from other products should not be used with a VENTOLIN HFA canister. Patients should be informed to discard VENTOLIN HFA when the counter reads 000 or 12 months after removal from the moisture-protective foil pouch, whichever comes first.

With the first use of a new canister, worsening of wheezing may occur. Ventolin inhaler – 100mcg Available in tablets – 4mg. Discontinue VENTOLIN HFA if immediate hypersensitivity reactions occur. The safety and effectiveness of VENTOLIN HFA administered with or without a spacer device in children under 4 years of age has not been demonstrated. atrial fibrillation, *Myocardial ischaemia (see section 4.4), Respiratory, thoracic and mediastinal disorders. There is some evidence from post-marketing data and published literature of myocardial ischaemia associated with salbutamol. These are similar to effects produced by the structurally related CFCs, which have been used extensively in metered-dose inhalers. Hypersensitivity reactions including angioedema, urticaria, bronchospasm, hypotension and collapse. In the management of premature labour.

In addition, beta-agonists have been reported to produce electrocardiogram (ECG) changes, such as flattening of the T wave, prolongation of the QTc interval, and ST segment depression. At therapeutic doses it acts on the beta-2 adrenoceptors of bronchial muscle providing short acting (4 to 6 hour) bronchodilation in reversible airways obstruction. Your healthcare provider has more information or advice. trailer An infusion rate of 10 to 45 micrograms/minute is equivalent to 0.5 to 2.25ml/minute of this solution. 1.

The dosage or frequency of administration should only be increased on medical advice. Other albuterol contraindications are related to other drugs the patient is taking, such as beta blockers. 2. During worldwide marketing experience, various congenital anomalies, including cleft palate and limb defects, have been reported in the offspring of patients being treated with albuterol. Rare cases of hypersensitivity reactions, including urticaria, angioedema, and rash have been reported after the use of albuterol sulfate. is this? Clinical studies of VENTOLIN HFA did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.

Systemic corticosteroids are frequently given during premature labour to enhance foetal lung development. Salbutamol administered intravenously has a half-life of 4 to 6 hours and is cleared partly renally and partly by metabolism to the inactive 4'-0-sulfate (phenolic sulfate) which is also excreted primarily in the urine. Concurrent administration of corticosteroids can exaggerate this effect. Bronchodilators should not be the only or main treatment in patients with severe or unstable asthma. In addition to the adverse reactions listed in section 6.1, the following adverse reactions have been identified during postapproval use of VENTOLIN HFA. Consider monitoring potassium levels. Exposure to temperatures above 120°F may cause bursting. In an 18-month study in CD-1 mice, albuterol sulfate showed no evidence of tumorigenicity at dietary doses of up to 500 mg/kg (approximately 1,700 times the maximum recommended daily inhalation dose for adults on a mg/m2 basis and approximately 800 times the maximum recommended daily inhalation dose for children on a mg/m2 basis). To prime VENTOLIN HFA, patients should release 4 sprays into the air away from the face, shaking well before each spray.

Mean Medication Delivery Through AeroChamber Plus (mcg/actuation), Medication Delivered per Actuation (mcg/kg)†. Date of first authorisation/renewal of the authorisation. Updated

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