Clin Lymphoma Myeloma Leuk 2012;12:406–411. Recently, small molecule inhibitors targeting a variety of kinases involved in the B-cell receptor pathway have demonstrated promising activity for the treatment of relapsed/refractory FL. Hoppe BS, Moskowitz CH, Zhang Z, . Philip T, Guglielmi C, Hagenbeek A, . Stephen D. Smith, MD, Panel Member, has disclosed that he receives grant/research support from Acerta Pharma, AstraZeneca Pharmaceuticals LP, Denovo Biopharm, Genentech, Inc., Incyte Corporation, Merchk Sharp Dohme Corporation, and Portola Pharmaceuticals, Inc.; he is a consultant for AstraZeneca Pharmaceuticals LP; and his spouse receives grant/research support from Ayala Pharmaceuticals, Bristol-Myers Squibb Company, and Ignyta Inc. Mary A. Dwyer, MS, CGC, Senior Manager, Guidelines, NCCN, has disclosed that she has no relevant financial relationships. Wirk B, Fenske TS, Hamadani M, . Individuals Who Provided Content Development and/or Authorship Assistance: Special Considerations for Use of PI3K Inhibitors, Guidance for Treatment With CAR T-Cell Therapy, Histologic Transformation After Minimal or No Prior Chemotherapy, Histologic Transformation After Multiple Lines of Prior Therapies, NCCN CATEGORIES OF EVIDENCE AND CONSENSUS, NCCN.org/disclosures/guidelinepanellisting.aspx, Article by Francisco Hernandez-Ilizaliturri. Haematologica 2017;102:e156–159. Moderate CYP3A Inhibitors: When CALQUENCE is co-administered with a moderate CYP3A inhibitor, reduce CALQUENCE dose to 100 mg once daily. In the JULIET trial, CRS and neurologic toxicity of any grade were reported in 58% and 21% of patients, respectively,38 and in 22% and 12%, respectively, for grade ≥3. Validation of POD24 as a robust early clinical endpoint of poor survival in follicular lymphoma: results from the Follicular Lymphoma Analysis of Surrogacy Hypothesis (FLASH) investigation using individual data from 5,453 patients on 13 clinical trials [abstract]. PharmacistsNCCN designates this knowledge-based continuing education activity for 1.0 contact hour (0.1 CEUs) of continuing education credit. Serious or Grade 3 or higher infections (bacterial, viral, or fungal) occurred in 19% of 1029 patients exposed to CALQUENCE in clinical trials, most often due to respiratory tract infections (11% of all patients, including pneumonia in 6%). Get the latest research from NIH: https://www.nih.gov/coronavirus. NCCN continuing education considers “relevant financial relationships” as financial relationships in any amount occurring within the past 12 months that create a conflict of interest. Parrott M, Rule S, Kelleher M, Wilson J. Monitor for symptoms of arrhythmia (e.g., palpitations, dizziness, syncope, dyspnea) and manage as appropriate. The mechanism is not well understood. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 2020 May 29;13:4877-4892. doi: 10.2147/OTT.S249586. Lerner RE, Thomas W, Defor TE, . Ardeshna KM, Qian W, Smith P, . This activity is supported by an independent educational grant from AbbVie. Bone Marrow Transplant 2009;43:941–948. The NCCN Guidelines Insights do not represent the full NCCN Guidelines; further, the National Comprehensive Cancer Network® (NCCN®) makes no representations or warranties of any kind regarding their content, use, or application of the NCCN Guidelines and NCCN Guidelines Insights and disclaims any responsibility for their application or use in any way. You may report side effects related to AstraZeneca products by clicking here. Monitor patients for skin cancers and advise protection from sun exposure.

Phosphatidylinositol 3-kinase (PI3K) inhibitors have shown promising results in the treatment of relapsed/refractory FL. NCCN does not set a minimal dollar amount for relationships to be significant. Nowakowski GS, LaPlant B, Macon WR, . J Clin Oncol 2017;35:3898–3905. Cell of origin of transformed follicular lymphoma. Colored markings in the algorithm show changes and the discussion aims to further the understanding of these changes by summarizing salient portions of the panel's discussion, including the literature reviewed. CRS and neurologic toxicity should be managed based on the toxicity grade as outlined in the CAR T-cell therapy–related toxicities section of the NCCN Guidelines for Management of Immunotherapy-Related Toxicities. Treatment for patients with relapsed/refractory mantle cell lymphoma: Sandoval-Sus JD, Sotomayor EM, Shah BD.

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