A decrease in chemotherapy drug, treatment efficacy (10). Macpherson et al studied higher-dose regimens by increasing the number of non–cross-resistant drugs and attempting to deliver therapy without treatment delays. Leuk Lymphoma.

30. Median overall survival was 7.7 months, and the median progression-free survival was also 7.7 months.

Levis et al reported results of a trial including 105 elderly HL patients in which all patients received a lower-intensity regimen, VEPEMB (vinblastine, cyclophosphamide, procarbazine, etoposide, mitoxantrone, bleomycin). Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use, Epidemiology of non‐Hodgkin's lymphoma in Connecticut, Non‐Hodgkin's lymphoma in the elderly. ASH Education Book 2008; 2008 (1): 341-48. http://dx.doi.org/10.1200/JCO.2006.10.5957, plete remission following a combination of very low in-, tensity chemotherapy with rituximab in an elderly pa, tient with Burkit's lymphoma. 7th International Symposium on Hodgkin Lymphoma (abstract I038). "Until recently, very elderly patients were systematically considered too frail to receive an appropriate treatment and were thus treated with low‐dose regimens. After stratification, the only difference in overall survival between patients who received anthracycline‐containing regimens and those who did not was observed in patients with high‐intermediate‐risk as determined by IPI score (P = 0.015). Rituximab as a single-agent in untreated and relapsed CD20-positive NLPHL is associated with objective response rates of 86% to 100%. When the results of the study were analyzed by age subgroups, we observed that whereas response and median survival were similar in patients aged 61 to 69 years or 70 years or older, there were significant differences in dose delivery and toxicity. Approximately 30% to 50% of all HL cases are EBV-positive, as identified by latent membrane protein (LMP)-1 or EBV-encoded RNA (EBER) immunostaining of the malignant cells.

An anthracycline‐containing regimen may … Weekes CD, Vose JM, Lynch JC, et al: Hodgkin’s disease in the elderly: Improved treatment outcome with a doxorubicin-containing regimen.

These data suggest that older age is associated with a worse prognosis in advanced DHL. Patients who had a good performance status at diagnosis had also a significant survival advantage. [4] In the most recent trial (CALGB 8251), 8% of patients were at least 60 years old. Number of times cited according to CrossRef: Low-Grade Lymphomas (Other than CLL/SLL) in Older Patients.

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